Phoenix Wound Matrix is a 3D electrospun synthetic polymer matrix designed to improve wound healing outcomes by addressing chronicity and persistent inflammation for the management of acute and chronic wounds, and burns.
Biomimetic, synthetic, electrospun scaffolds provide the starting point for in situ tissue engineering (TE).
In situ TE is defined as biomaterial-induced endogenous regeneration directly in the tissue’s functional site starting from a resorbable device that gradually transforms into an autologous, homeostatic replacement tissue with the ability to repair, remodel, and grow (Wissing, et al, 2017).
The approach of in situ TE is built on the notion that the natural inflammatory response can be harnessed to induce endogenous tissue regeneration. The resorbable immunomodulatory scaffold provides a temporary microenvironment, which functions as an instructive road map for endogenous cells to infiltrate and create new, living, and functional tissue. It is hypothesized that, upon implantation, the scaffold provides support for mature tissue formation and adequate mechanical properties to withstand the hemodynamic loads. Over time, the scaffold should slowly resorb, ultimately resulting in a purely biological structure which has the ability to repair, remodel, and grow.